A naturalistic study of plasma lipid alterations in female patients with anorexia nervosa before and after weight restoration treatment

Table 3 Plasma concentrations of lipids and sex hormones

Variables	AN pre (T₀)	AN post (T₁)	Difference AN	p value AN pre versus AN post	HC	p value HC versus AN pre
N	75	75			26
BMI (kg/m²)	15.3 (3.4)	18.9 (2.9)	2.4 (2.8)	< 0.001	22.4 (2.9)	< 0.001
Total cholesterol (mmol/L)	4.9 (1.2)	4.9 (1.4)	0.1 (1.0)	0.2	4.3 (0.7)	0.003
HDL (mmol/L)	2.0 (0.5)	1.9 (0.6)	− 0.03 (0.2)	0.4	1.7 (0.6)	0.06
LDL (mmol/L)	2.3 (1.0)	2.4 (1.0)	0.07 (0.8)	0.4	2.3 (0.9)	0.8
VLDL (mmol/L)	0.5 (0.3)	0.5 (0.3)	0.03 (0.4)	0.1	0.4 (0.2)	0.7
FFA (mmol/L)	0.1 (0.1)	0.1 (0.1)	0.01 (0.1)	0.4	0.2 (0.3)	0.1
TG (mmol/L)	1.2 (0.8)	1.1 (0.7)	− 0.04 (0.9)	0.6	0.9 (0.3)	0.006
Estradiol (nmol/L)	0.05 (0.1)	0.09 (0.1)	0.02 (0.1)	0.06	0.3 (0.3)	< 0.001
Testosterone (nmol/L)	0.5 (0.7)	0.4 (0.6)	0 (0.3)	0.7	0.8 (0.5)	0.03
Progesterone (nmol/L)	0.5 (0.5)	0.6 (0.4)	0.05 (0.5)	0.6	1.9 (27.6)	0.8
SHBG (nmol/L)	44.1 (32.1)	33.5 (21.1)	− 9.9 (18.3)	< 0.001	43.4 (14.7)	0.98
FSH (IU/L)	4.1 (5.3)	5.2 (3.3)	0.7 (3.4)	0.03	4.9 (2.3)	0.2
LH (IU/L)	1.2 (7.9)	4.5 (8.6)	1.5 (4.1)	< 0.001	6.8 (3.8)	< 0.001

All results are reported as median (IQR). IQR = interquartile range, AN pre = patients with anorexia nervosa, pre-treatment/at baseline (T₀), AN post = patients with anorexia nervosa, post-treatment/at follow-up (T₁), HC = healthy control participants, N = number, BMI = body mass index, HDL = high-density lipoprotein cholesterol, LDL = low density lipoprotein cholesterol, VLDL = very low density lipoprotein cholesterol, FFA = free fatty acids, TG = triglycerides, SHBG = sex-hormone binding globulin, FSH = follicle stimulating hormone, LH = luteinizing hormone
p value: differences were assessed by the nonparametric test on the equality of medians, and the difference in the AN group before and after weight restoration was assessed by Wilcoxon matched-pairs signed-rank test. Bold font = signifcant results

ISSN: 2050-2974